Collagenase NB 6 GMP Grade from Clostridium histolyticum

Nordmark GMP enzymes - highest quality and safety for clinical applications

For applications which have to meet GMP requirements like tissue engineering and transplantation.
Collagenase NB 6 GMP Grade is applicable to tissue dissociation such as isolation of human ADSCs, stem cells, chondrocytes, fibroblasts, neuronal and endothelial cells.


Contains class I and class II collagenase (1) and a balanced ratio of proteolytic side activities.
PZ activity (Wünsch): ≥ 0.100 U/mg
Microbiological examination: Sterility, absence of Clostridia, abnormal toxicity (general safety test; Ph. Eur.).
Sterile according to Ph. Eur.
Manufactured according to EU GMP guidelines.
(Clostridiopeptidase A)
EC • Mr ca. 70 000 - 120 000 (collagenases) • CAS [9001-12-1]

Order Information

Productname Cat.No Size EUR
Collagenase NB 6 GMP Grade N0002779 1 g Inquire+
Collagenase NB 6 GMP Grade N0002880 100 mg Inquire+

+Please use the inquiry form in the right column.

Storage Temperature: +2 °C to +8 °C

Related Products

Since Collagenase NB 6 GMP Grade is designed for clinical applications under GMP requirements, Nordmark also offers an equivalent product for initial protocol and application establishment. Collagenase NB 4 Standard Grade has comparable enzymatic properties to Collagenase NB 6 GMP Grade and is a cost effective alternative for protocol optimization. Furthermore, if a sterile product is needed, Collagenase NB 5 Sterile Grade (Cat. No. N0002778) might also be used in order to establish applications.

References and Definitions

Unit definition: 1 U according to Wünsch (2) catalyzes the hydrolysis of
1 µmole 4-phenylazobenzyloxycarbonyl-L-prolyl-L-leucylglycyl-L-prolyl-D-arginine per minute at 25 °C, pH 7.1.

1. Bond, M.D. & van Wart, H.E. (1984) Biochemistry 23, 3077-3091
2. Wünsch, E. & Heidrich, H.G. (1963) Hoppe-Seyler's Z. Physiol. Chem. 333, 149-51

Safety Information

Signal word


Hazard Statements

H315 - H317 - H319 - H334 - H335




P302 +P352 - P304 +P340 - P305 +P351 +P338 - P342 +P311 - P362 +P364

EINECS: 232-582-9 • WGK: 1 • HS: 35079090

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