Ancrod project – From raw venom to highly purified drug substance

Until 2019, Ancrod was isolated as a biologically active substance from the venom of the Malayan Pit Viper (Calloselasma rhodostoma) at Nordmark’s biocentre. Ancrod is a fibrinogen splitting enzyme (fibrinogenase), which may be therapeutically significant in a number of indications. Fibrinogenase works by lowering the level of fibrinogen in blood, leading to a reduction of blood viscosity.

Collecting the snake venom
Collecting the snake venom
Chromatographic purification in the clean room
Chromatographic purification in the clean room
Dried raw venom as the starting material for drug substance manufacturing
Dried raw venom as the starting material for drug substance manufacturing
Vials after formulation and filling
Vials after formulation and filling